相关实验视频

Updated: Jan 9, 2026

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

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LRRK2 集成了 Rab 和 GABARAP 相互作用,以感知和响应不同的 lysosomal 压力

Devin Clegg1,2,3,4,5, Amanda Bentley-DeSousa1,2,3,4,5, Agnes Roczniak-Ferguson1,2,3,4,6,5

  • 1Departments of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

bioRxiv : the preprint server for biology
|December 3, 2025
PubMed
概括

在帕金森病中,富含白的重复激酶2 (LRRK2) 激活与溶解体功能有关. 这项研究揭示了LRRK2如何通过Rab GTPases和GABARAP蛋白质感知 lysosomal变化.

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Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

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