全脑千秒级有效连接 听觉和视觉命名的马拉松
bioRxiv : the preprint server for biology
|December 3, 2025
概括
这项研究表明,定向的神经信息流,特别是刺激突发,支持语音处理. 大脑区域之间的短暂激发性流动使语音转换成为可能,更快的命名与更强的定向流动有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 语音产生的模型是遥远的皮层区域之间的相互作用,由白质连接在一起.
- 以前的研究将功能性协作激活 (同时高马活性) 与神经相互作用联系起来,但缺乏对整个大脑的定向洞察力.
- 语音处理中的信息流的时间动态和方向性仍然不清楚.
研究的目的:
- 在听觉和视觉命名任务中调查定向神经信息流的因果作用.
- 了解如何短暂的信息传输动态有助于整个大脑层面的语音处理.
- 将特定的信息流模式与语音响应时间和刺激诱导的症状联系起来.
主要方法:
- 在命名任务中利用了来自127名患者的9526个部位的内脑电图 (iEEG) 数据.
- 估计使用基于传输的有效连接的定向信息流,将其分类为刺激性或抑制性.
- 分析了信息流的时间演变,其与功能协作激活的关系,以及与临床结果的相关性.
主要成果:
- 刺激性信息流从感官皮层开始,传播到更高层次的区域,并变得双向.
- 每个激发性流动都是短暂的 (<500毫秒),经常跟随着抑制性流动和通路激活的转变.
- 更快的命名与特定皮层区域更强的激发性流动相关 (听觉的左半球,视觉的双边基本时).
- 更强烈的刺激流预测了刺激诱导的症状,特别是视觉命名期间的语音停顿,超过了协同激活措施.
结论:
- 通过白质路径介导的短暂,定向的神经相互作用对于语音处理的连续阶段至关重要.
- 激发性和抑制性流动的动态相互作用使命名所需的功能过渡成为可能.
- 这项研究提供了因果证据,证明了暂时精确的白质通路在语音中的作用,扩展了神经生物学模型.
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