年轻成年人吸烟量与抑郁症状之间的因果关系:来自新型交叉滞后双胞胎模型的证据
medRxiv : the preprint server for health sciences
|December 3, 2025
概括
年轻的成年人在吸烟量 (每天一支香烟) 和抑郁症状 (DepSx) 之间经历了强化反循环. 这些双向效应在长达两年的时间内是显著的,但在更长的时间内会消失.
科学领域:
- 精神病学是一个精神病学.
- 行为科学 行为科学
- 遗传学 是一个遗传学.
背景情况:
- 吸烟和抑郁症在年轻人中经常同时发生.
- 假设潜在的共同病因因素和相互因果关系.
- 纵向双胞胎研究对于解开这些关系至关重要.
研究的目的:
- 为了测试吸烟量 (CigDay) 和抑郁症状 (DepSx) 之间的因果假设.
- 采用新的生物识别交叉滞后面板模型 (CLPMs) 进行强大的因果推断.
- 整合双胞胎发育和因果关系方向分析.
主要方法:
- 利用了来自双胞胎早期发育研究的10,034名参与者的数据 (61.6%是女性,4,112对双胞胎).
- 从21-29岁进行了多达六次重复评估.
- 具有明显的遗传/环境自回归过程和交叉滞后负债的应用生物识别CLPM.
主要成果:
- 对CigDay和DepSx的遗传责任在约4年内保持稳定,而环境影响则有所变化.
- 标准CLPM显示CigDay预测DepSx;然而,生物识别CLPM减弱了这些影响.
- 发现了显著的双向近接效应,CigDay→DepSx路径更强.
结论:
- 这些发现支持吸烟和年轻成年人抑郁症之间的反循环.
- 双向效应持续长达两年.
- 这些效应在较长的时间间隔中消散,这表明了动态相互作用.
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