脉冲压对认知的影响的变化基于血压的变化
medRxiv : the preprint server for health sciences
|December 3, 2025
概括
脉压升高预示着老年人的认知能力下降,特别是那些血压升高的人. 监测脉压可以提高认知风险评估,并为血压管理策略提供信息.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 心血管健康 心血管健康
背景情况:
- 脉压 (PP) 是静缩和静缩血压之间的差异,是老年人认知障碍的新兴预测因素.
- 与血压状况相对的PP的预测值及其在血压类别上的差异效应仍然不清楚.
研究的目的:
- 在65岁及以上的成年人中,研究脉冲压与认知能力下降在10年内之间的联系.
- 为了确定脉冲压是否预测认知能力下降独立于血压状态,以及这种关联是否受到血压水平的调节.
主要方法:
- 利用了来自ACTIVE试验的2802名参与者的数据.
- 采用线性混合效应模型来评估脉冲压,血压状况和全球认知,记忆,推理和处理速度在十年内下降之间的关系.
主要成果:
- 较高的脉冲压与更快的全球认知衰退有显著的关联,在记忆和推理领域一致.
- 在调整血压状况后,这种关联仍然显著,表明了补充的预测效用.
- 脉压对认知能力下降的有害影响,特别是在血压升高的参与者身上观察到,而不是在血压正常的参与者身上.
结论:
- 脉压与老年人加速认知衰退有关,这种关系受到血压状况的调节.
- 脉压监测可以提高高血压的老年人认知风险评估.
- 有效的血压管理对于减轻与脉压增加相关的认知衰退至关重要.
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