揭示肥胖中高血压的荷尔蒙机制
Stéfanie Parisien-La Salle1,2, Cheng-Hsuan Tsai1,3,4, Andrew J Newman1
1Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Metabolism, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
medRxiv : the preprint server for health sciences
|December 3, 2025
概括
与肥胖相关的高血压涉及荷尔蒙失衡,超过80%的患者表现为阿尔多斯特隆主义或高皮质醇主义. 这些发现支持针对肥胖个体高血压的向治疗.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与肥胖相关的高血压是一种复杂的疾病,其荷尔蒙支柱尚未完全理解.
- 了解这些激素机制对于开发有效的向疗法至关重要.
研究的目的:
- 研究与肥胖相关的高血压相关的荷尔蒙表型.
- 为了表征 adrenocortical 激素的产生,以响应动态刺激和抑制测试.
主要方法:
- 在77名患有肥胖和高血压的参与者中深度表型化上腺皮质激素.
- 使用坐着的盐水抑制 (SST),口服负荷 (OSLT),德克萨抑制测试 (DST) 和ACTH刺激 (ACTHstim).
- 参与者被分类为原发性阿尔多斯顿主义 (PA),低蛋白和依赖蛋白的阿尔多斯顿主义表型.
主要成果:
- 在基线时,37.7%的人具有PA表型;在SST后,这一数字增加到51.9%,揭示了以前没有掩盖的病例.
- 在SST后23.4%的患者中,发现了持续的氨酸依赖性阿尔多斯特,阿尔多斯特和卡利乌雷斯水平较高.
- DST在9.2%的参与者中发现了ACTH独立的高皮质醇症.
结论:
- 超过80%的参与者表现出异常的阿尔多斯特隆主义和/或高皮质醇主义表型.
- 这些荷尔蒙失调突显了肥胖中高血压的多因素性质.
- 这些发现支持针对肥胖个体高血压的阿尔多和皮质醇向疗法.
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