兄弟姐妹精神疾病和产后精神病的风险
Shelby Smout1,2, Floriana Milazzo2, Thalia K Robakis2
1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
medRxiv : the preprint server for health sciences
|December 3, 2025
概括
家庭精神病史,特别是兄弟姐妹的双相情感障碍和精神分裂情感障碍,显著增加了产后精神病的风险. 这突显了遗传联系,并支持将分娩后精神病视为严重情绪障碍.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 生殖健康 生殖健康
背景情况:
- 产后精神病 (PP) 影响1000名女性中的1-2名.
- 确定的危险因素包括双相情感障碍和以前的PP.
- 家庭精神病史在PP风险中的作用尚不清楚.
研究的目的:
- 调查兄弟姐妹精神病诊断与产后精神病风险之间的关联.
- 确定家族精神病史是否有助于PP风险,特别是在没有先前精神疾病的女性中.
主要方法:
- 利用瑞典国家登记册识别了1,213,829名1980-2017年间分娩的有全身兄弟姐妹的妇女.
- 产后精神病被定义为在产后90天内出现的躁狂,精神病或精神病性抑郁症.
- 使用后勤回归来估计关联,控制女性自己的精神病史.
主要成果:
- 1831名妇女 (1000人中有1.5人) 患有分娩后精神病.
- 发现的最强的关联是姐妹的PP (OR 10.84),循环心血症 (OR 8.29),精神分裂情绪障碍 (OR 7.90) 和双相情感障碍 (OR 5.00).
- 兄弟姐妹诊断显著增加了PP风险,特别是在没有先前精神病史的女性中.
结论:
- 产后精神病表现出强烈的家族聚合,与各种兄弟姐妹诊断相关的风险.
- 关联的模式,特别是双极性,循环性和精神分裂情绪障碍,表明PP是严重情绪障碍谱的一部分.
- 家庭精神病史是一个重要的,经常被忽视的,产后精神病的危险因素.
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