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在早产婴儿的支气管肺功能障碍的血液学参数:一个元分析

Hongyu Li^1,2, Jia Fan³, Hehua Du^1,2

¹Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in pediatrics

|December 3, 2025

概括

这项系统性审查发现,在患有或没有支气管肺功能障碍 (BPD) 的婴儿之间,中性粒细胞,血红蛋白,血红素和血小板数量存在显著差异. 然而,关键的血液学参数如HCT,PLT和HGB并不是BPD的显著独立风险因素.

科学领域:

新生儿医学新生儿医学
肺部病理学肺部病理学
血液学血液学血液学

背景情况:

支气管肺功能障碍症 (BPD) 是早产婴儿的一种严重的慢性肺病.
关于血液学参数 (HPs) 和BPD的现有研究显示出不一致的结果.

研究的目的:

系统地审查和元分析早产婴儿中HP和BPD之间的关联.
澄清HP在BPD发展中的作用及其作为诊断标记物的潜力.

主要方法:

来自主要数据库的20项研究 (4,752名参与者) 的系统审查和元分析.
遵守PRISMA指南和使用纽卡斯尔-太华尺度进行质量评估.
使用 Stata 18 和 MetaDisc. 的统计分析.

主要成果:

在中性粒细胞 (NEU),血红蛋白 (HGB),血红素 (HCT),红细胞 (RBC),血小板 (PLT) 数,中性粒细胞与淋巴细胞的比率 (NLR) 和全身炎症反应指数 (SIRI) 中观察到的显著差异. BPD和非BPD婴儿.
在BPD婴儿中增加了NEU,NLR和SIRI,减少了HGB,HCT,RBC和PLT.
HCT,PLT和HGB不是BPD的统计学上显著的独立风险因素;NLR和PLT显示出有限的诊断能力 (ROC-AUC~0.67).

结论:

虽然某些HP在BPD和非BPD婴儿之间有显著差异,但HCT,PLT和HGB等关键参数可能不是独立的风险因素.
需要进一步的大规模,多中心的前性研究来证实这些发现,并探索诊断潜力.

关键词:

支气管肺功能失调症支气管肺功能失调症肺部发育不良症肺部发育不良症这是一个元分析.血小板血小板是过早出生的婴儿早产.

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