通过生物信息学和系统生物学技术解读COVID-19和糖尿病病之间的相互作用
Xianxiang Chen1, Qingle Zeng2, Min Xia3
1The First Clinical Medical College, Guangxi Medical University, Nanning, China.
Biochemistry and biophysics reports
|December 3, 2025
概括
这项研究确定了COVID-19和糖尿病病 (DN) 之间的共同分子通路和枢纽基因,揭示了潜在的治疗标. 研究结果支持精准医学用于管理这些并发性疾病.
科学领域:
- 生物信息学和系统生物学
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 糖尿病病 (DN) 是糖尿病的一种严重并发症. 患有DN的患者受到COVID-19流行病的影响不成比例.
- 了解COVID-19和DN之间的分子联系对于有效管理至关重要.
研究的目的:
- 为了研究COVID-19和DN之间的分子相互作用.
- 确定协同临床管理的共享机制和潜在的治疗目标.
主要方法:
- 对COVID-19 (GSE171110) 和DN (GSE30528) 的转录组数据集进行分析,以识别差异表达基因 (DEG).
- 蛋白质与蛋白质相互作用 (PPI) 和转录因子 (TF) -微RNA (miRNA) 调节网络的构建.
- 药物基因关联的探索和使用接收器操作特征 (ROC) 曲线验证枢纽基因.
主要成果:
- 确定了COVID-19和DN之间83个重叠的DEG,突出显示了共享的途径,如血细胞系和补充/凝固级流.
- 发现了五个关键的枢纽基因 (IL7R,CD2,GZMA,CD3D,FCER1A) 参与免疫调节和组织损伤.
- 确定了潜在的药物重新定位候选者 (例如,α-d-曼诺斯,阿司匹林) 和具有高诊断潜力的验证的枢纽基因 (AUC>0.80).
结论:
- 共享的分子通路和枢纽基因为共患COVID-19和DN的免疫失调和组织损伤提供了洞察力.
- 针对IN-7受体的向策略和已识别的生物标志物显示出改善临床结果的前景.
- 综合生物信息学在复杂的疾病相互作用中对精准医学有价值.
更多相关视频
相关概念视频
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Chronic Kidney Disease III: Interprofessional Care
323
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
323
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Nephrotic Syndrome I : Introduction
470
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
470
Chronic Kidney Disease I: Introduction
545
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
545


