使用MMINT在GEM中的代谢网络的探索和比较可视化
Juan P Molina Ortiz1,2, Matthew J Morgan1,2,3, Amy M Paten1,2
1CSIRO Environment, Canberra, ACT 2601, Australia.
iScience
|December 3, 2025
概括
本研究介绍了代谢建模交互网络工具 (MMINT),用于探索基因组规模代谢模型 (GEM) 流动分布. MMINT有助于可视化和比较代谢网络,以识别表型驱动因素.
科学领域:
- 系统生物学 系统生物学
- 代谢工程是代谢工程.
- 计算生物学 计算生物学
背景情况:
- 基因组规模代谢模型 (GEMs) 对于模拟生物途径和预测表型至关重要.
- 解释复杂的GEM输出需要有效的可视化工具.
研究的目的:
- 引入代谢建模交互网络工具 (MMINT) 以加强GEM流量分布网络的探索和比较.
- 为了方便识别潜在的特定表型的代谢驱动因素.
主要方法:
- MMINT允许在GEM中交互切换代谢物和反应.
- 该工具突出了预测流量分布之间的相似之处和差异.
- 使用*Pyrococcus furiosus* GEM (iPfu) 进行了MMINT的证明.
主要成果:
- MMINT有效地可视化和比较GEM流量分布.
- 该工具成功地在P. furiosus*中区分了酸盐和乙醇生产表型的代谢驱动因素.
- MMINT为模型探索提供了直观和响应式的用户体验.
结论:
- MMINT简化了对GEM模拟输出的解释.
- 该工具支持研究人员识别细胞表型的关键代谢途径和驱动因素.
- MMINT增强了GEM在系统和合成生物学研究中的实用性.
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