细胞内细胞结构与固体瘤预后的相关性 - - 一个元分析
Haoyi Zi1,2, Yinhai Dai1,3, Mengxuan Li2
1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China, sntcm.edu.cn.
BioMed research international
|December 3, 2025
概括
细胞内细胞结构 (CIC) 是癌症预后的新兴生物标志物. 这项元分析发现,总体CIC和淋巴细胞在瘤 (LiT) 结构的较高数量与固体瘤的整体存活率较差有关.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物标志物 生物标志物
背景情况:
- 细胞内细胞结构 (CIC) 代表了复杂的细胞相互作用,在癌症中具有潜在的预后价值.
- 固体瘤中CICs的预后意义需要进一步澄清.
- 这项研究解决了关于CICs作为预测瘤结果的预测生物标志物的不确证据.
研究的目的:
- 在实体瘤中进行元分析,评估细胞内细胞结构 (CICs) 的预后价值.
- 评估整体CIC (oCIC) 与预后之间的关联.
- 研究特定CIC亚型的预后意义:瘤中的瘤 (TiT),瘤中的巨细胞 (TiM),瘤中的巨细胞 (MiT) 和瘤中的淋巴细胞 (LiT).
主要方法:
- 在PubMed,Web of Science和Cochrane图书馆进行了系统的文献搜索,直到2024年10月.
- 包括报告关于固体瘤中CICs预后的研究.
- 通过使用NICE质量评估工具评估研究质量,并遵循MOOSE指南.
主要成果:
- 分析包括1836名OCIC患者和429名CIC亚型患者.
- 总体CIC (oCIC) 的较高数量与不良的整体存活率 (OS) (HR = 1.64,p = 0.003) 有关.
- 瘤中的淋巴细胞 (LiT) 结构也成为OS的显著不良预后因素 (HR = 1.43,p = 0.005).
- 瘤中的瘤 (TiT),瘤中的巨 (TiM) 和瘤中的巨 (MiT) 亚型在本分析中没有显著的预后价值,可能是由于研究数量有限.
结论:
- 总体细胞内细胞结构 (oCICs) 的增加是固体瘤的不良预后因素.
- 瘤中的淋巴细胞 (LiT) 结构也与较差的整体存活率有关.
- 这些发现凸显了OCIC和LiT作为固体瘤患者潜在可靠的预后指标.
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