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Updated: Jan 9, 2026

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
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Published on: August 2, 2021

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通过SPHK1-介导的M2巨细胞两极化驱动TGF-β1-依赖的血栓纤维化

Xiaoyun Chen1, Fajiu Li2, Guofeng Ma3

  • 1The School of Clinical Medicine, Fujian Medical University, Department of Respiratory and Critical Care Medicine, Fujian Provincial Geriatric Hospital, Fuzhou, China.

Frontiers in immunology
|December 3, 2025
PubMed
概括

斯芬哥辛激酶1 (SPHK1) 通过促进M2巨细胞两极分化来驱动血栓纤维化. 用PF543抑制SPHK1可降低纤维化和M2巨细胞极化,为慢性血栓栓塞性肺高血压 (CTEPH) 提供潜在的治疗点.

关键词:
在M2巨细胞中,M2巨细胞这就是SPHK1的原因.在TGF-β1中.纤维化 纤维化一个单细胞测序.静脉血栓的形成 静脉血栓的形成

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