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在胃癌中,内网和中性粒细胞与淋巴细胞的比率之间的相关性

Masahiro Takeuchi^1,2, Chise Shiraishi¹, Yurika Fukudome^1,2

¹Department of Surgery, Yamaguchi Rosai Hospital, Sanyo-Onoda, JPN.

|December 3, 2025

概括

在胃癌患者中,中性粒细胞与淋巴细胞比率 (NLR) 的升高与中性粒细胞细胞外陷 (NETs) 的增加和生存结果的降低相关. NLR和NET可以作为可访问的预后工具.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物生物标志物

背景情况:

系统性炎症影响癌症的进展和预后.
中性粒细胞与淋巴细胞的比率 (NLR) 是各种癌症的预后因素.
在胃癌中NLR和中性粒细胞外细胞陷 (NETs) 的作用需要进一步澄清.

研究的目的:

在胃癌中调查术前NLR和内NET之间的关联.
评估NLR和NET在胃癌患者的预后意义.

主要方法:

对52名经过治疗性手术的胃癌患者的回顾性分析.
基于手术前NLR (≥3.5比<3.5) 的患者分层.
评估系统NLR,组织NET密度和整体存活率之间的相关性.

主要成果:

与低NLR组 (3.98年) 相比,高NLR组的中位生存时间 (2.60年) 显著减少.
在瘤组织中,在NLR和NET密度之间发现了中度的正相关性 (r=0.507,p=0.0001).

结论:

升高的NLR与胃癌的生存率低下有关.
在瘤微环境中,NLR与NET形成具有正相关性.
NLR和组织NET显示出作为胃癌可访问的预后标记物的潜力.

关键词:

胃癌胃癌是一种胃癌.中性粒细胞外细胞陷中性粒细胞淋巴细胞比率.预后预后预后手术手术手术手术手术手术手术

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