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在接受基于西斯的化疗的癌症患者中维持功能中的N-乙半氨酸的作用

Oryza Gryagus Prabu¹, Nabilah Nurul Islami¹, Jesslyn Mellenia¹

¹Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

International journal of nephrology and renovascular disease

|December 3, 2025

概括

通过抵消其毒性作用,N-乙半氨酸 (NAC) 在预防西斯普拉丁诱导的急性损伤 (AKI) 中表现有前途. 虽然临床前数据很强,但需要进一步的临床试验来确认NAC.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

西斯普拉丁是固体瘤的重要化疗,但导致剂量依赖性毒性,导致高达45%的患者急性损伤 (AKI).
目前用于预防西斯普拉丁诱导的AKI的策略有限,并提供可疑的临床结果.
具有抗氧化和抗炎性能的安全化合物N-乙半氨酸 (NAC) 正在研究其脏保护潜力.

研究的目的:

审查基底的机制,西斯普拉丁诱导的AKI.
探索N-乙半氨酸 (NAC) 在预防西斯普拉丁诱导的AKI中的作用.
评估目前支持NAC在预防西斯胺诱导的AKI的有效性的证据.

主要方法:

进行了临床前和临床研究的叙述性审查.
研究的重点是评估N-乙半氨酸 (NAC) 在预防西斯普拉丁诱导的AKI方面的疗效.

主要成果:

西斯普拉丁通过破坏管细胞,增加活性氧物种 (ROS),并引起线粒体功能障碍和炎症来诱导AKI.
N-乙半氨酸 (NAC) 通过清除ROS和补充谷氨来抵消这些影响,在临床前研究中证明了脏保护作用.
临床研究结果对NAC的疗效是不一致的,因为样本大小小小,剂量多样化,以及管理途径.

结论:

N-乙半氨酸 (NAC) 具有显著的脏保护性,这是由一致的临床前数据所证明的.
尽管目前临床证据有限,但NAC是预防西斯普拉丁诱导的AKI的一个有希望的药物.
未来的研究需要大规模的标准化临床试验,优化NAC剂量,以证实其疗效和临床效用.

关键词:

这是一种N-乙囊氨酸.急性脏损伤急性脏损伤是什么西斯普拉丁 (cisplatin) 是一种制剂.这是一种神经保护性药物.

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