用于预测医院获得的静脉血栓栓塞在机械呼吸的ICU患者的诺姆图:一个回顾性队列研究
Wenjie Ge1, Aiqin Chu1, Zhimin Cao1
1Department of Nursing, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Frontiers in medicine
|December 3, 2025
概括
一种新型的诺米图准确地预测了医院获得的静脉血栓塞栓症 (HA-VTE) 在机械通风的ICU患者中. 这种工具有助于早期识别和个性化预防策略对重症患者.
科学领域:
- 关键护理医学 关键护理医学
- 血管外科 血管外科
- 流行病学 流行病学
背景情况:
- 医院获得的静脉血栓塞栓症 (HA-VTE) 是重症监护室 (ICU) 患者的重大并发症,特别是那些接受机械呼吸的人.
- 早期识别和风险分层对于实施有效的预防措施和减少患者发病率和死亡率至关重要.
研究的目的:
- 开发和验证用于早期识别需要机械通风的成年ICU患者HA-VTE的预测性名录.
- 为临床医生建立一个实用的工具来分层HA-VTE风险,并指导个性化预防策略.
主要方法:
- 对472名接受机械呼吸的成年ICU患者的回顾性分析.
- 静脉瘤的客观诊断通过成像研究得到证实.
- 后勤回归分析以确定HA-VTE的独立风险因素.
- 使用AUC-ROC,校准曲线,Hosmer-Lemeshow测试和决策曲线分析 (DCA) 评估的已识别的预测因素开发和验证名录.
主要成果:
- 在研究队列中观察到HA-VTE率为12.50% (59例).
- 确定了六个独立的预测因素:中风,卧床状态 (≥3天),卡普里尼风险评分,格拉斯哥昏迷表,纤维素和d-二次体.
- 诺米图显示出优异的分辨率 (AUC 0.909) 和高校准精度 (p=0.603),DCA显示出显著的临床实用性.
结论:
- 一个经过验证的纳米图,包含六个可访问的临床预测因素,有效地分层了机械通风ICU患者的HA-VTE风险.
- 这种工具有助于早期干预和个性化预防,可能减少与HA-VTE相关的并发症和医疗保健成本.
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