急性胰腺炎患者症状进展的时间动态:动态时间扭曲分析
Rui Han1, Xiaoyu Deng2, Hebing Liu3
1School of Nursing, Jilin University, Changchun, China.
Frontiers in medicine
|December 3, 2025
概括
动态时间变形 (DTW) 有助于分析急性胰腺炎 (AP) 中复杂的症状变化. 这种方法确定了六个症状集群,并发现食欲变化显著影响患者体验,有助于个性化AP管理.
科学领域:
- 医疗信息学医学信息学
- 计算生物学是一种计算生物学.
- 医疗服务研究 医疗服务研究
背景情况:
- 急性胰腺炎 (AP) 发病率正在上升,随着时间的推移,患者表现出复杂,可变的症状.
- 传统的分析方法与AP症状进展的动态和异质性质作斗争.
- 动态时间扭曲 (DTW) 提供了一种新的方法来建模这些复杂的时间动态.
研究的目的:
- 系统地分析使用DTW的AP患者的个性化症状轨迹.
- 在AP的时间序列变化期间探索症状集群的异质特征.
- 为个性化AP症状管理提供一个方法框架.
主要方法:
- 一项对155名AP患者进行的纵向研究,在出院12个月后评估了32种症状.
- 动态时间扭曲 (DTW) 应用于时间症状数据,以创建个别距离矩阵.
- 差距分析,层次聚类和网络分析用于组级聚类识别和中心症状确定.
主要成果:
- 在所有AP患者中观察到个性化的症状模式和动态变化.
- 鉴定了六个不同的症状集群:情绪,食欲,多系统的身体,局部感知,功能下降和腹部不适.
- 与食欲相关的症状具有很高的中心性,表明对其他患者体验有很大的影响.
结论:
- DTW是一种有效的方法,用于分析个人和团体的时间症状轨迹在AP.
- 研究结果支持个性化的症状管理,早期干预策略和AP的预测建模.
- 这项研究为推进AP患者护理提供了经验证据和方法支持.
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