囊素C和基于肌素的eGFR的差异与多种心血管疾病的风险之间的关联:前性队列研究
Zhiyu Qiao1, Xinyi Liu1, Hao Liu1
1Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Frontiers in medicine
|December 3, 2025
概括
基于囊素C和肌素的估计球过率 (eGFRdiff) 之间的差异与不良结果有关. 负的eGFRdiff显著增加死亡率和心血管疾病 (CVD) 风险,突出了针对性预防策略的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 生物标志物 生物标志物
背景情况:
- 基于囊素C和肌素的估计球过率 (eGFRdiff) 之间的差异与不良健康结果有关.
- 了解eGFRdiff的预后价值对于患者管理至关重要.
研究的目的:
- 综合评估eGFRdiff与全因死亡率之间的关联.
- 评估与eGFRdiff相关的多种心血管相关疾病的风险.
主要方法:
- 分析了来自297140名参与者的英国生物库数据.
- 将eGFRdiff分为负 (<-15),中间 (-15到15) 和正 (≥15毫升/分钟/1.73米) 的组.
- 使用了Cox比例危险回归模型和灵敏度分析.
主要成果:
- 负的eGFRdiff与所有原因死亡率 (1.44),心血管疾病发病率 (1.49) 和心血管疾病死亡率 (1.25) 的危险比率增加显著相关.
- 负的eGFRdiff组显示了所有10个研究的CVD相关疾病的风险更高.
- 每10毫升/分钟/1.73米2的EGFRdiff增加与疾病发病率下降10-19%相关.
结论:
- eGFRdiff是死亡率,心血管疾病发病率和相关疾病的重要预测指标.
- 研究结果强调了为减少eGFRdiff的个体制定有针对性的预防策略的重要性.
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