左侧核的体积与关节骨关节炎的睡眠不足有关
Natalia Egorova-Brumley1, Luiza Bonfim Pacheco1,2, Gabby Knox3
1Melbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia.
Neurobiology of pain (Cambridge, Mass.)
|December 3, 2025
概括
在关节骨关节炎 (OA) 中,左侧内核 (NAc) 体积减少与睡眠质量和效率低下有关. 这种关联在OA的女性中可能更明显,突出了睡眠.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 睡眠医学 睡眠医学
背景情况:
- 缩小核体积 (NAc) 是慢性疼痛过渡的潜在生物标志物,包括骨关节炎 (OA).
- 睡眠障碍在OA中很普遍,可能会影响疼痛感知.
- 在睡眠障碍和疼痛感知中NAc的作用需要进一步研究.
研究的目的:
- 调查左侧NAc体积与部OA患者的睡眠质量/数量之间的关联.
- 探索这种关系中潜在的基于性别的互动.
主要方法:
- 一项涉及34名患有中度关节OA的参与者的横截面研究.
- 使用神经成像评估左侧NAc体积.
- 使用匹兹堡睡眠质量指数 (PSQI) 评估睡眠质量和数量.
主要成果:
- 在部OA队列中,左侧NAc体积明显低于规范值.
- 较差的睡眠质量,特别是较低的睡眠效率,显著预测了较小的左NAc体积.
- 一个趋势表明,睡眠效率较低的女性左NAc体积较小,尽管经过校正后在统计学上并不显著.
结论:
- 睡眠质量,特别是睡眠效率,会影响慢性关节骨关节炎患者左侧NAc体积的减少.
- 这些发现扩大了之前关于睡眠和疼痛的研究,使其适用于临床OA人群.
- 左NAc可以作为对睡眠障碍敏感的疼痛生物标志物,特别是在OA的女性中.
相关概念视频
Substance Use Disorders Affecting Sleep
369
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
369
Sleep-Wake Cycles
2.7K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K
Management of Insomnia
507
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
507
Insufficient Sleep and Sleep Deprivation
807
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
807
Narcolepsy
466
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
466
REM Sleep Behavior Disorder
1.3K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
1.3K


