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在中高收入国家和地区跟踪母性百日咳疫苗接种覆盖率的进展 - - 一项系统性审查和建模研究

Xiyu Zhang^1,2,3, Tianshuo Zhao^1,2,3, Tiancheng Xie^1,2,3

¹Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191 China.

EClinicalMedicine

|December 3, 2025

概括

孕产妇百日咳疫苗 (MPV) 覆盖率在全球范围内增加到2019年,然后下降,特别是在高收入国家. 改善MPV吸收对于保护婴儿免受 pertussis至关重要,特别是在流行后.

科学领域:

公共卫生公共卫生
流行病学流行病学
疫苗学疫苗学疫苗学

背景情况:

孕产妇百日咳疫苗 (MPV) 对于保护婴儿免受百日咳的侵害至关重要.
全球和区域MPV覆盖率的趋势仍然被不充分理解.
本研究分析了高收入国家与官方疫苗政策的MPV覆盖率.

研究的目的:

估计2015-2023年全球和国家MPV覆盖率和趋势.
为了确定影响MPV覆盖范围随时间变化的因素.
为改善婴儿防保护的策略提供信息.

主要方法:

系统的文献综述和贝叶斯模型.
包括来自214篇文章和官方数据来源的936个国家/年MPV覆盖记录.
分析15个高收入和中高收入国家的MPV覆盖率趋势,推Tdap疫苗.

主要成果:

全球MPV覆盖率显示了一个反转的U形趋势:从2015-2019年增加 (EAPC:6.34%) 并从2020-2023年减少 (EAPC:-1.15%).
高收入国家覆盖率下降更为明显,美国,巴拿马和阿根廷对经济衰退做出了重大贡献.
美国的MPV覆盖率在2019年至2023年期间下降了近13%.

结论:

对于预防婴儿百日咳而言,MPV覆盖率至关重要,但需要改进.
观察到的MPV覆盖率下降,可能会因大流行病而加剧,需要有针对性的干预措施.
需要持续努力,以确保高MPV吸收率,并保护脆弱的婴儿.

关键词:

免疫接种免疫接种孕产妇的疫苗接种方式百日咳百日咳是一种疾病.接种疫苗的覆盖范围

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