肠道微生物分泌物可能触发单核细胞迁移,并在炎症性肠病和糖尿病视网膜病变之间提供并发症机制
Bingyu Xu1, Shuduan Wu2,3, Junfei Huang1
1The Second Clinical School, Southern Medical University, Guangzhou, Guangdong, China.
Mediators of inflammation
|December 3, 2025
概括
肠道微生物及其炎症分泌物,如胆酸,有助于炎症性肠病 (IBD) 和糖尿病视网膜病变 (DR) 的并发症. 这项研究揭示了肠道失调如何加剧视网膜炎症和DR进展.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
背景情况:
- 肠道微生物群通过分泌的化学物质,如胆酸 (BAs) 和L-kynurenine,影响炎症.
- 研究肠道微生物及其分泌物在炎症性肠病 (IBD) 和糖尿病视网膜病变 (DR) 并发症中的作用至关重要.
研究的目的:
- 分析IBD和糖尿病患者的特定肠道微生物.
- 为了确定这些微生物分泌的促炎化学物质.
- 阐明肠道微生物及其分泌物在IBD-DR并发症机制中的功能性作用.
主要方法:
- 在IBD和DM患者中分析肠道微生物群和分泌的化学物质.
- 对外围血液单核细胞 (PBMC) 的基因表达分析 (DEG,WGCNA).
- 单细胞分析以了解并发症的细胞学机制.
主要成果:
- 异常肠道微生物 (例如,BA,L-Kynurenine) 的分泌物刺激异常免疫反应.
- 来自失生性肠道微生物群 (Veillonella,Clostridium) 的促炎物质激活PBMCs,破坏血管屏障,并恶化DR.
- 促进PBMC迁移的基因 (RSU1,FN1,CD9) 被激活,显示出一种遗传性并发症机制.
- IBD促进效应记忆T (Tem) 细胞的增殖和激活,在DR中也升高,为并发症提供细胞基础.
结论:
- IBD患者的异常肠道细菌分泌有助于炎症的物质,激活单核细胞,特别是Tem细胞.
- 激活的单核细胞迁移到视网膜,加剧了DR.
- 了解这种肠-视网膜轴为DR治疗提供了潜在的治疗策略.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
925
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
925
01:17Chronic Bowel Disorders: Introduction
734
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
734
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
862
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
862
01:17Irritable Bowel Syndrome I: Introduction
893
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
893
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
617
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
617
01:17Gastritis-II: Pathophysiology
1.1K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.1K