在2001-2022年期间异形性肺纤维化死亡率的全球趋势
Ko Harada1, Yoshito Nishimura2, Quynh Thi Vu3
1Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ERJ open research
|December 3, 2025
概括
全球异常性肺纤维化 (IPF) 死亡率正在上升,特别是在男性中. 这一趋势凸显了IPF率在年龄,性别和地理位置上的显著差异,需要有针对性的公共卫生干预措施.
科学领域:
- 肺病学和流行病学.
- 全球健康趋势 全球健康趋势
- 慢性疾病死亡率 慢性疾病死亡率
背景情况:
- 异形性肺纤维化 (IPF) 是一种致命的,渐进的肺病,全球最新的死亡率数据有限.
- 了解当前全球IPF死亡率趋势对于公共卫生规划和疾病管理至关重要.
研究的目的:
- 分析目前与异常性肺纤维化 (IPF) 相关的死亡率的全球趋势.
- 为了确定IPF死亡率在不同的人口和地区的差异.
主要方法:
- 利用世界卫生组织的死亡数据库 (2001-2022) 进行观察性分析.
- 计算每10万个人的原始和年龄标准化死亡率,按性别,年龄和地区分层.
- 使用局部加权回归和结点回归用于趋势分析.
主要成果:
- 分析了874,998起与IPF相关的死亡事件;到2022年,原始死亡率从每10万人中2.10增加到3.14
- 年龄标准化利率在2018年达到峰值 (每10万人口1.59),到2022年略有下降至1.57.
- 在男性,65岁以上的个人和美国人口中观察到较高的死亡率,拉丁美洲的死亡率增加.
结论:
- 全球IPF死亡率呈现越来越高的趋势,特别是在男性中.
- 在IPF死亡率方面存在显著的地理,年龄和性别差异,需要有针对性的公共卫生战略.
- 改善疾病管理对于解决IPF观察到的全球死亡趋势至关重要.
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