术后放射治疗对宏壮壮病的长期影响:来自伊朗单中心宏壮壮病登记处的结果
Farzad Najafipour1, Javad Jafarpour1, Amir Bahrami1
1Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
International journal of endocrinology
|December 3, 2025
概括
传统的放射疗法 (RT) 在15年后的术后壮症患者中有效控制生长激素 (GH). 然而,这种治疗与高发生率的hypopituitarism有关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 神经外科 神经外科
背景情况:
- 巨症是由生长激素 (GH) 过度分泌引起的,导致代谢问题.
- 治疗选择包括手术,药物治疗和放射治疗 (RT).
- RT可以生化控制壮症,单独或与医疗治疗.
研究的目的:
- 评估手术后壮症患者常规RT的长期有效性.
- 在15年的随访期内评估生化控制和副作用.
主要方法:
- 在手术后对55名壮病患者进行了回顾性分析,这些患者接受了常规RT治疗 (中位数为52 Gy).
- 平均随访时间为15年.
- 激素评估 (GH,IGF-1) 和评估RT相关的副作用.
主要成果:
- 在RT后的2,5年和10年,GH水平显著下降 (p < 0.001).
- 在60%的患者中,在15年内达到IGF-1水平正常化.
- 高发病率的hypopituitarism (78%,低甲状腺症80%,低皮质素化82%的10年) 和神经方面的并发症 (4%的10年).
结论:
- 传统的RT是一种有效的长期治疗,用于对手术或药物无反应的巨.
- 晚期出现的阴下垂体是需要仔细考虑的显著副作用.
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