在墨西哥队列中,MTHFR C677T与自闭症谱系障碍无关
Mirna Edith Morales-Marín1, Omar Náfate-López2, Amalia Guadalupe Gómez-Cotero3
1Laboratorio de Genómica de las Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Frontiers in psychiatry
|December 3, 2025
概括
在墨西哥自闭症谱系障碍 (ASD) 患者中研究了MTHFR C677T基因变异. 这项研究没有发现MTHFR C677T变异与该人群中的ASD之间存在显著的关联.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 人口研究 人口研究
背景情况:
- 自闭症谱系障碍 (ASD) 的病因是复杂的,可能涉及遗传因素.
- 甲基四叶酸减少酶 (MTHFR) C677T变体已被研究其在ASD风险中的潜在作用.
- 之前对MTHFR C677T变体和ASD的研究已经产生了有争议的结果.
研究的目的:
- 调查墨西哥人口中MTHFR C677T变体 (rs1801133) 和ASD之间的关联.
- 在墨西哥的ASD患者中进行这种特定变异的第一个病例控制关联分析.
主要方法:
- 案例控制关联研究设计.
- 在MTHFR C677T变体 (rs1801133) 的基因定型.
- 统计分析比较ASD病例和对照个体之间的等位基因频率.
主要成果:
- 在研究的墨西哥人群中,MTHFR C677T变体和ASD之间没有发现显著的关联.
- 在ASD病例和对照组之间,C和T等位基因的等位基因频率没有显著差异 (OR = 0.9698,P = 0.7858).
结论:
- 在研究的墨西哥人群中,MTHFR C677T变异似乎不是ASD的重要风险因素.
- 除了MTHFR C677T之外,与祖先相关的遗传因素可能在这个人群中对ASD的病因起到更重要的作用.
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