早期EEG和血清生物标志物用于心脏骤停后的预后
Inken Alina Strate1, Johannes G Krabbe2,3, Sjoukje Nutma1,4
1Clinical Neurophysiology (CNPH), Technical Medical Center, University of Twente, Drienerlolaan 5, 7500 AE Enschede, the Netherlands.
神经纤维光链 (NfL) 在预测心脏骤停后的神经结果方面表现有前途. 将NfL与早期脑电图 (EEG) 结合起来可以改善预后,特别是在不确定的病例中.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 早期脑电图 (EEG) 有助于对昏迷状态心脏骤停 (CA) 幸存者的预后,但有局限性.
- 血清生物标志物可以提高结果的预测,特别是在未确定的EEG发现的情况下.
研究的目的:
- 评估血清生物标志物神经元特异性酶 (NSE),神经丝光链 (NfL),S100B和p-Tau 181在与早期EEG相结合时的附加预后值.
主要方法:
- 一项试点研究分析了昏迷患者在CA后多个时间点的血清生物标志物度.
- 脑电图被评估在12小时和24小时,神经结果 (大脑性能类别) 被评估在6个月.
主要成果:
- 血清生物标志物度在CA后24小时内神经结果不佳的患者中较高.
- 与其他生物标志物相比,NfL显示出更好的预后性能 (AUC 0.90).
- NfL>128 pg/mL实现了100%的特异性,用于未确定EEG发现的患者的不良结果.
结论:
- 与其他测试的血清生物标志物相比,NfL显示出优越的预后性能.
- 将NfL与早期EEG (12-24小时) 结合起来可能会增加预后价值,特别是对于不确定的EEG结果.
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