抗微生物耐药性处于转折点:微生物驱动因素,一个健康,以及全球未来
Ayman Elbehiry1, Eman Marzouk1, Adil Abalkhail1
1Department of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Frontiers in microbiology
|December 3, 2025
概括
抗菌素耐药性 (AMR) 是一个日益增长的全球威胁. 通过"一个健康"的方法和先进的诊断,整合微生物,临床和环境数据对于有效的监测和管理至关重要.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 环境科学 环境科学
背景情况:
- 抗菌素耐药性 (AMR) 构成了21世纪重要的健康危机,危及现代医学和感染控制.
- 抗菌耐药性的驱动因素包括微生物进化,基因转移,人类/兽医滥用,农业和环境因素.
- 整合微生物,临床和环境视角的"一个健康"框架对于应对这种复杂威胁至关重要.
研究的目的:
- 审查和整合微生物,临床和环境对抗微生物药物耐药性 (AMR) 的观点.
- 突出诊断和抗菌药物管理方面的进步,并确定监测和政策中的持续差距.
- 建议对抗抗菌素耐药性的优先方向,强调综合监测和基于实验室的方法.
主要方法:
- 综合微生物,临床和环境数据的当前文献的审查.
- 分析诊断方面的进展,如MALDI-TOFMS,WGS,数字PCR和基于CRISPR的测试.
- 检查抗微生物药物管理策略和One Health联系.
主要成果:
- 抵抗机制涉及突变,基因转移和生物膜,环境储作为传播管道.
- 诊断和监控工具正在进步,但面临着不均的部署,特别是在资源较少的环境中.
- 有效的管理需要综合监督和政策,连接农业,环境和临床背景.
结论:
- 基因组学知情监测和先进诊断是打击AMR的关键.
- 临床微生物学实验室可以作为诊断,管理和综合监测的中心中心.
- 将实验室发现转化为可采取行动的决策对于患者的治疗结果和全球公共卫生至关重要.
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