肺癌患者的营养管理,同时接受放射治疗和免疫治疗,并发展出与免疫有关的皮肤炎:一个病例报告
Yanlin Zeng1, Xinmei Zhang2, Di Qin2
1Department of Radiotherapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Frontiers in nutrition
|December 3, 2025
概括
本案例报告详细介绍了一个营养不良的非小细胞肺癌 (NSCLC) 患者的营养管理,该患者同时接受放射治疗和免疫治疗. 阶段性营养支持和运动改善了结果,有助于治疗完成和皮肤炎愈合.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 放射治疗和免疫治疗.
背景情况:
- 患有局部晚期非小细胞肺癌 (NSCLC) 的老年患者经常因手术或化疗的禁忌而接受同时进行放射治疗和免疫治疗.
- 这些患者面临营养不良和与治疗相关的不良事件的高风险,对营养管理的数据有限.
- 本案例报告涉及严重营养不良的NSCLC患者的营养管理,该患者正在接受化学放射治疗和免疫治疗.
研究的目的:
- 要总结一个非小细胞肺癌 (NSCLC) 患者的营养管理过程,该患者患有严重营养不良,同时接受放射治疗和免疫治疗.
- 突出管理营养缺陷和免疫相关不良事件,特别是皮肤炎的挑战和策略.
- 评估分阶段营养方法与运动康复相结合的有效性.
主要方法:
- 一名患有肺状细胞癌和严重营养不良的71岁男性接受了同时进行放射治疗和tislelizumab免疫治疗.
- 使用营养状况的动态评估,目标设定,及时调整营养处方.
- 关键干预措施包括结合肠道和肠道营养,调整肠道配方,免疫营养素补充剂和指导性运动训练.
主要成果:
- 患者患有2级辐射诱导食道炎和3级免疫相关皮肤炎.
- 阶段性营养管理导致营养指标在住院54天内显著改善.
- 患者成功完成了抗瘤治疗,皮肤炎愈合.
结论:
- 全程管理,包括分阶段的营养策略和运动康复,可以有效地改善营养状况,并促进NSCLC患者的皮肤炎愈合.
- 这种综合方法支持成功完成抗癌疗法.
- 需要进一步研究更大的样本大小来证实这些发现.
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