维生素D缺乏和慢性脊髓损伤中的神经病痛:一个横截面研究
Tengbin Shi1, Yanfeng He2, Zhengxi Yu3
1Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, China.
Frontiers in nutrition
|December 3, 2025
概括
维生素D缺乏在脊髓损伤 (SCI) 患者中很常见,并且强烈预测神经病痛 (NeP). 维生素D水平较低显著增加了SCI后发生NeP的风险.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 康复医学 康复医学 康复医学
背景情况:
- 脊髓损伤 (SCI) 经常导致神经病痛 (NeP),损害患者的功能和康复.
- 维生素D缺乏症在SCI人群中普遍存在,原因是阳光照射和移动性减少等因素.
- 维生素D在慢性SCI相关NeP中的特定作用尚不清楚.
研究的目的:
- 调查维生素D状况与慢性创伤性SCI的成年人中NeP的患病率之间的联系.
- 根据血清维生素D水平来确定NeP的潜在预测截止值.
主要方法:
- 一项涉及182名患有慢性创伤性SCI (损伤后≥6个月) 的成年人的横截面研究.
- 使用HPLC-MS/MS.测量的血清25-基维生素D [25(OH) D]水平.
- 通过DN4问卷和临床评估诊断NeP;使用多变量逻辑回归和ROC曲线分析分析关联.
主要成果:
- 尼普的患病率为52.7%;64.8%的参与者有维生素D缺乏或不足.
- 较低的维生素D水平与较高的NeP风险独立相关.
- 血清25(OH) D水平<16.35 ng/mL被确定为NeP的预测指标 (AUC=0.812).
结论:
- 维生素D缺乏是慢性SCI中NeP的显著和独立预测因素.
- 在SCI患者中,可能需要进行常规的维生素D缺乏症查.
- 需要进一步进行干预试验,以确认维生素D补充剂在SCI相关NeP的治疗作用.
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