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高强度多菌株益生菌配方用于安全和改善胃肠功能和肠道健康:一项随机对照临床试验
Xinru Zhang1, Ying Wu1,2, Yiru Jiang1
1College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
高强度益生菌Wec600B和Wec1000B显著改善了成年人的胃肠道症状和肠道健康. 这些益生菌增强了有益的肠道细菌,减少了炎症和肠道损伤.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 胃肠道功能障碍影响全球人口的20-40%,影响生活质量.
- 益生菌可以通过调节微生物群,增强表皮屏障功能和调节免疫反应来改善肠道健康.
研究的目的:
- 评估两种高强度益生菌配方Wec600B和Wec1000B在患有胃肠功能障碍的成年人中的疗效和安全性.
- 评估这些益生菌对胃肠道症状,免疫标记物,肠道屏障功能和肠道微生物群组成的影响.
主要方法:
- 一项随机对照试验,涉及100名被诊断患有胃肠功能障碍的成年人 (18-65岁).
- 参与者接受了Wec600B (1200亿CFU/天) 或Wec1000B (2000亿CFU/天) 在4周内.
- 评估安全性,症状改善,免疫/炎症生物标志物,肠道屏障功能,以及干预前后的肠道微生物群多样性.
主要成果:
- Wec600B和Wec1000B都显著改善了胃肠道症状 (消化不良,疼痛,反流,便秘,腹),没有任何不良事件.
- 炎症标志物 (便calprotectin,NGAL,FL) 和肠道损伤指标 (DAO,D-LA,LPS) 的水平降低.
- 增加了分泌IgA,丰富了有益的肠道细菌 (Bifidobacterium,Lactobacillus,Blautia,Collinsella),并减少了致病性细菌 (Prevotella,Escherichia-Shigella,Klebsiella).这些细菌可以在肠道中产生.
结论:
- 高强度益生菌Wec600B和Wec1000B在改善胃肠道症状和增强肠道健康方面是有效的.
- 机制包括调节肠道微生物群,减少炎症,加强肠道屏障功能.
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