双胞胎怀孕期间维生素D的长度变化:与母婴结局的关联
Zhentong Dai1, Lin Zhang1, Xintong Shi1
1Shengjing Hospital of China Medical University, Shenyang, China.
Frontiers in nutrition
|December 3, 2025
概括
在怀孕中期,母亲的维生素D (VD) 缺乏会增加双胞胎怀孕中自发早产的风险. 在此期间优化VD水平对于防止不良结果至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 营养科学 营养科学
背景情况:
- 维生素D (VD) 缺乏与单独怀孕的不良结果有关.
- 在双胞胎怀孕中,静脉疾病水平对母亲和新生儿健康的影响尚不清楚.
研究的目的:
- 调查双胞胎怀孕中母亲的静脉疾病水平与怀孕结果之间的关联.
- 探索双胞胎怀孕中VD状态和新生儿人类学之间的关系.
主要方法:
- 在324例双胞胎怀孕中,在怀孕中期和晚期测量了血清VD水平.
- 后勤回归和受限立方线 (RCS) 分析了静脉疾病与自发早产 (sPTB) 和其他并发症的关联.
- 敏感性分析和多重归算解决了缺少的数据.
主要成果:
- 怀孕中期的VD缺陷独立预测了sPTB (OR:2.19).
- 观察到VD水平和sPTB风险之间的L形关系,每1ng/mL减少VD增加14.94%的sPTB风险.
- 没有发现母亲的静脉疾病水平与怀孕的高血压疾病,妊娠糖尿病,阳性早产或新生儿出生体重之间有显著的关联.
结论:
- 在怀孕中期保持适当的母体静脉疾病水平对于预防双胞胎怀孕中的sPTB至关重要.
- 对缺乏维生素的女性来说,补充维生素的时间可能是关键的.
- 虽然VD状态没有显著影响新生儿人体测量,但持续监测对于母亲和新生儿的福祉至关重要.
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