神经发育编程中的神经活性类固醇:对孕产妇肥胖的影响
Carmen J Zamora-Sánchez1, Juan Carlos González-Orozco2, Jonatan Mendoza-Ortega1,3
1Department of Immunobiochemistry, National Institute of Perinatology, Mexico, Mexico.
Frontiers in endocrinology
|December 3, 2025
概括
孕产妇的肥胖可能会在怀孕期间破坏关键的神经活性类固醇,影响胎儿的大脑发育,增加后代神经发育障碍的风险. 了解这些影响是改善婴儿神经发育结果的关键.
科学领域:
- 神经内分泌学神经内分泌学
- 发育神经科学的发展神经科学.
- 生殖生物学 生殖生物学
背景情况:
- 神经活性类固醇对胎儿大脑发育至关重要,调节神经发生和突触发生等关键过程.
- 神经活性类固醇通路的干扰与神经发育和情绪障碍有关.
- 孕产妇超重和肥胖是全球越来越严重的健康问题,可能会对怀孕和胎儿发育产生影响.
研究的目的:
- 审查神经活性类固醇在胎儿神经发育中的作用.
- 综合证据,关于母亲的肥胖如何影响神经活性类固醇在怀孕期间的新陈代谢.
- 探索这些改变对后代神经发育不良结果的贡献.
主要方法:
- 文献综述综合临床前和临床证据.
- 在胎儿编程过程中分析神经活性类固醇生物合成和功能.
- 检查母亲超重/肥胖对母亲-胎盘-胎儿单位的影响.
主要成果:
- 神经活性类固醇对于正常的胎儿大脑成熟至关重要.
- 孕产妇的肥胖会引起代谢和荷尔蒙的变化,这些变化会干扰神经活性类固醇的合成和功能.
- 肥胖怀孕中神经活性类固醇代谢的改变与自闭症谱系障碍,多动症多动症和后代认知障碍的风险增加有关,通常具有性别特异性影响.
结论:
- 孕产妇的肥胖症通过改变神经活性类固醇路径对胎儿神经发育构成重大风险.
- 需要进一步的研究来理解这些复杂的相互作用.
- 确定新的生物标志物和治疗点对于减轻肥胖母亲后代的不良神经发育结果至关重要.
相关概念视频
01:07Teratogenicity
3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:22Diabetes Mellitus: Type 2 and Gestational
4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
02:30Genomic Imprinting and Inheritance
36.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.7K
01:29Drugs Affecting Neurotransmitter Synthesis
2.1K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.1K
01:21Drug Dosing: Obese Patients
189
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
189