便基甲基化合成甘-2试验和便免疫化学试验用于中国人口中晚期结直肠瘤查:多中心随机非比较性研究
Yufeng Chen1,2, Jiaxin Li3,4, Kai Gu5
1Department of General Surgery (Colorectal Surgery) and Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases and Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Chinese medical journal
|December 3, 2025
概括
甲基化Syndecan-2 (mSDC2) 便试验在检测中国晚期结直肠瘤方面显示出有效性. 这种查策略还表明,与便免疫化学测试 (FIT) 相比,结肠镜检查的遵守率提高.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 分子诊断学 分子诊断
背景情况:
- 在中国,结肠直肠癌 (CRC) 发病率正在上升,这挑战了目前的查方法.
- 该研究解决了在中国人口中需要有效的CRC查策略的需求.
- 在便中测试甲基化Syndecan-2 (mSDC2) 基因正在作为一种新的查方法被探索.
研究的目的:
- 评估基于便的mSDC2测试用于检测晚期结直肠瘤的可行性.
- 为了比较mSDC2测试和便免疫化学测试 (FIT) 之间的晚期结直肠瘤检测率.
- 根据便测试的阳性结果,评估结肠镜粘附性.
主要方法:
- 一项多中心随机研究,涉及44475名年龄在45-80岁之间的参与者.
- 参与者被随机分配,接受mSDC2测试或FIT.
- 阳性结果导致了结肠镜转诊;检测率和坚持是主要和次要结果.
主要成果:
- mSDC2测试在0.53%的参与者中检测到晚期瘤,而FIT在0.47%中检测到.
- 具体发现包括先进的腺瘤,先进的状息肉和CRC病例在两个测试.
- 与FIT组 (26.4%) 相比,mSDC2试验组 (35.6%) 的结肠镜粘附率显著更高.
结论:
- 无论mSDC2和FIT测试都是有效的检测在现实中文环境中发达结直肠瘤.
- mSDC2测试可以提高对建议的结肠镜后续检查的坚持.
- 需要进一步的研究来确认临床效用,并优化可比性和后续协议.
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