在患有纤维肌痛的女性中评估过度活跃的膀,表现出下游尿路症状:一项受控临床研究
Duygu Kurtulus1, Kevser Arkan2, Ferhat Yakup Suceken3
1Ümraniye Training & Research Hospital, Department of Physical Therapy and Rehabilitation, Health Sciences University, İstanbul, Turkey.
Neurourology and urodynamics
|December 3, 2025
概括
过度活跃的膀 (OAB) 影响了超过60%的纤维肌痛 (FM) 妇女,显著恶化了他们的疼痛和并发症. 这表明OAB可能与FM患者的中央敏感性有关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 类风湿病学 类风湿病学
- 疼痛医学 医学 疼痛医学
背景情况:
- 纤维肌痛 (FM) 是一种慢性疼痛疾病,通常与下泌尿道症状 (LUTS) 相关.
- 患有FM的女性中过度活跃膀 (OAB) 的患病率和临床意义尚不清楚.
- 这项研究调查了FM患者的OAB患病率,并比较了他们的临床特征.
研究的目的:
- 为了确定被诊断为纤维肌痛的妇女中OAB的患病率.
- 为了比较患有FM和OAB的女性的临床特征与患有FM但没有OAB的女性,以及对OAB的对照.
- 探索OAB和FM症状严重程度,疾病持续时间和并发症之间的关系.
主要方法:
- 一项涉及232名女性的横截面受控研究 (192名女性患有肺炎,40名女性为对照).
- 在OAB诊断中使用了国际禁欲协会的标准,过度活动膀意识工具 (OAB-V8) 和3天的膀日记.
- 使用广泛疼痛指数 (WPI),症状严重程度尺度 (SSS) 和一般症状评分 (GSS) 评估了FM症状负担.
主要成果:
- 在FM患者中,OAB被诊断为62.0%,对照组为28.6% (p < 0.001).
- 患有OAB的FM患者年龄较大,疾病持续时间较长,报告WPI,SSS和GSS得分较高.
- 在FM+OAB组中,精神病并发症,刺激性肠综合征 (IBS) 和肥胖更频繁. 在OAB和FM症状严重程度之间存在中度的相关性.
结论:
- 过度活跃的膀在患有纤维肌痛的女性中非常普遍且具有临床意义.
- 在FM中,OAB与症状严重程度的增加和并发症负担的增加有关.
- 这些发现支持这样一个假设,即FM中的OAB可能是中央敏感化的表现.
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