在COVID-19大流行期间,在手术后存在静脉血栓栓塞的风险
Andrew Jackson1,2, David J Humes1,2, Amir Mehrkar3
1Gastrointestinal and Liver Theme, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Anaesthesia
|December 3, 2025
概括
在手术后,COVID-19感染显著增加了静脉血栓栓塞 (VTE) 的90天风险. 然而,接种疫苗可以降低这种VTE风险,这凸显了疫情期间免疫的重要性.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染与更高的静脉血栓栓塞 (VTE) 发病率有关.
- 关于COVID-19大流行期间和接种疫苗后VTE风险如何演变的数据有限.
- 这项研究旨在评估疫情期间90天的术后静脉瘤风险.
研究的目的:
- 在COVID-19大流行期间评估术后静脉血栓栓塞 (VTE) 的90天风险.
- 为了调查SARS-CoV-2感染状况和静脉突风风险之间的关联.
- 为了确定疫苗接种对术后风险的影响.
主要方法:
- 一项回顾性队列研究利用了OpenSAFELY-TPP平台.
- 包括接受重大外科手术的患者 (腹部,产科,骨科,心脏,胸部,血管).
- 使用Cox的比例危险模型计算了90天VTE的原始风险和衍生的危险比率.
主要成果:
- 分析了180多万项手术,90天内发生了15390起VTE事件.
- 手术后的SARS-CoV-2感染增加了4.4倍的静脉瘤风险 (aHR4.42).
- 未接种疫苗的患者面临着最高的VTE风险;一剂疫苗剂量减少了20%的风险 (aHR 0.80).
结论:
- 感染SARS-CoV-2状态和疫苗接种史显著影响90天VTE风险.
- 最近和手术后的SARS-CoV-2感染都会增加静脉瘤风险.
- 一剂COVID-19疫苗与VTE风险的降低有关.
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