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关于儿科中益生菌的最新情况
Maria Zemła1, Maja Kotowska-Bąbol, Hania Szajewska
1Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland.
Current opinion in clinical nutrition and metabolic care
|December 3, 2025
概括
最近的儿科益生菌研究证实了2023年欧洲儿科胃肠病学,肝病学和营养学会 (ESPGHAN) 对肠道疾病的指导方针. 新证据尚未支持对这些菌株特定的益生菌建议进行更改.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 临床试验 临床试验
背景情况:
- 益生菌经常用于儿科护理,但它们的有效性因特定菌株和健康状况而异.
- 2023年,欧洲儿科胃肠病学,肝病学和营养学会 (ESPGHAN) 制定了针对儿科胃肠道问题的菌株特定指南.
研究的目的:
- 审查2024年以后发表的科学文献.
- 确定新出现的证据是否需要对儿童胃肠道疾病现有的ESPGHAN益生菌建议进行修改.
主要方法:
- 对2024年以来发表的研究进行系统审查.
- 对临床试验数据的分析,分析了儿童群体中益生菌的疗效.
- 将新发现与2023年ESPGHAN指南进行比较.
主要成果:
- 建议使用乳酸菌菌 rhamnosus GG (LGG) 和Saccharomyces boulardii,以预防与抗生素相关的腹.
- 像L. reuteri DSM 17938和B. lactis BB-12这样的特定益生菌显示出婴儿和功能性腹痛的潜力.
- 目前不建议服用益生菌治疗便秘,预防死肠炎的证据仍然有限.
结论:
- 自2024年以来的当前研究还没有提供足够的数据来改变已建立的ESPGHAN益生菌建议.
- 益生菌在儿科中的有效性仅限于少数菌株和特定适应症.
- 需要进一步的大规模,多中心研究,使用标准化的方法来加强证据基础.
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