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特定站点的囊体修改使得AAV的FRα导向重定位能够用于精确的基因传递

Yuanjie Zhang1,2,3,4, Yingying Shi1,2,3,4, Xueying Zhou1,2,3,4

  • 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Molecular pharmaceutics
|December 3, 2025
PubMed
概括

工程设计的腺相关病毒 (AAV) 载体使用叶酸受体α (FRα) 更有效地向癌细胞. 这种精确的基因疗法方法提高了输送效率,并减少了用于改善癌症治疗的非目标效应.

关键词:
腺相关病毒的病毒.叶酸的修改 叶酸的修改基因治疗的基因疗法遗传密码扩展 扩展 遗传密码不自然的氨基酸是一种非自然的氨基酸.

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