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Updated: Jan 9, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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设计和合成Pyrazolomorphinan衍生物作为新的三角形阿片类受体对抗剂

Hideaki Fujii1,2, Chiharu Iwamatsu1, Saki Ishizaki1

  • 1Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Journal of medicinal chemistry
|December 3, 2025
PubMed
概括

研究人员开发了具有独特化学结构的新型 δ阿片类受体 (DOR) 激动剂. 化合物SYK-1106在小鼠中表现出强大的DOR激素和类似抗抑郁药的效果,提供了一个有前途的新治疗途径.

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