为患有食道癌症的患者提供术前短期营养和运动试验计划:一项随机临床试验:胸腔瘤学
Sanshiro Kawata1, Yoshihiro Hiramatsu2,3, Junko Honke4
1Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Annals of surgical oncology
|December 3, 2025
概括
对食管癌手术患者进行的为期2周的预康复计划增加了蛋白质摄入量,但没有显著改善心肺功能或体力活动水平. 需要进一步的研究来优化预康复策略的外科治疗结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 心肺生理学 心肺生理学
背景情况:
- 消化管切除术与术后并发症的高发病率有关.
- 改善手术前的患者状况对于更好的手术结果至关重要.
- 预康复计划旨在在重大手术前提高患者的健康状况.
研究的目的:
- 为了评估一个为期2周的多模式预康复计划的有效性.
- 评估对食道癌患者手术前心肺功能的影响.
- 为了确定无氧值 (AT) 和体力活动的变化.
主要方法:
- 一个平行组,开放标签,优越性随机临床试验.
- 参与者被随机分配到多式预康复 (m-prehab) 组或对照组.
- 在m-prehab组接受了运动和营养支持,而对照组接受了标准的护理.
主要成果:
- 与对照组相比,m-prehab组的蛋白质摄入量显著增加.
- 在手术前的每日步数或无氧值 (AT) 的变化之间没有观察到显著的差异.
- 在m-prehab组中,四肢肌肉强度显著增加,骨肌肉指数增加的趋势.
结论:
- 预康复计划成功增加了手术前的蛋白质摄入量.
- 该计划没有导致身体活动或手术前变化AT显著改善.
- 这些发现表明,目前的预康复方案可能需要优化,以提高这种患者群体的心肺功能.
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