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在FFPE结直肠腺癌样本中,富里埃变换中红外成像和快速蒸发性电离质谱成像

B Borkovits¹, Cs Török², E Kontsek³

¹Department of Biological Physics, ELTE Eötvös Loránd University, Budapest, Hungary.

Pathologie (Heidelberg, Germany)

|December 3, 2025

概括

这项研究结合了红外光谱学 (IR) 和质谱学 (MS) 进行结直肠癌分析. 多式联络方法显示出有希望的准确性,支持其临床诊断潜力.

科学领域:

在瘤学瘤学.
分析化学分析化学
医学诊断医学诊断医学诊断

背景情况:

匈牙利面临着高的结直肠癌发病率和死亡率.
新的分析技术正在医学中出现.
多模式IR和MS在临床环境中未得到充分利用.

研究的目的:

评估一种结合IR和MS的多式联络方法,用于结直肠癌分析.
评估光谱学和光谱学在区分组织类型方面的有效性.
探索用于改进癌症诊断的新型分析方法.

主要方法:

准备了结直肠组织的组织微阵列 (TMA).
红外 (IR) 光谱和质谱 (MS) 在相同的TMA截面上进行.
数据分析涉及到噪声过和分类算法 (SVC,XGBoost).

主要成果:

处理了41个组织核心.
红外光谱学在SVC和XGBoost两种情况下都实现了0.71的分类精度.
多发性硬化症的分析显示分类准确度为0.65和0.70.
算法性能可比,表明了组合方法的可行性.

结论:

通过IR和MS分析的相同的TMA幻灯片显示了可比的算法性能.
综合光谱和光谱法方法对结直肠癌的分析是有效的.
未来的工作包括将光谱数据与数字整片图像集成,并优化测量厚度.

关键词:

有涂层的.癌症癌症癌症癌症雷姆斯 (Reims) 公司截面厚度截面厚度这就是TMAMA的意义.

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