使用Rhizopus spp.进行乳酸发酵. :当前的见解和未来的前景.
Mst Mahmoda Akter1,2, Marium Akter Jim3, Brandon Gilroyed4,5
1School of Environmental Sciences, University of Guelph Ridgetown Campus, 120 Main Street East, Ridgetown, ON, N0P 2C0, Canada.
Bioresources and bioprocessing
|December 3, 2025
概括
类真菌从可再生能源中高效地产生乳酸 (LA),比细菌更有优势. 本综述详细介绍了真菌LA生产,生物工艺优化和可持续应用的技术经济可行性方面的进展.
科学领域:
- 生物技术和工业微生物学
- 生物化学工程 生物化学工程
- 可持续化学 可持续化学
背景情况:
- 乳酸 (LA) 是一种关键的有机酸,需求日益增加,特别是在可生物降解的多乳酸 (PLA) 生产中.
- 使用Rhizopus物种的真菌发酵比细菌方法具有优势,包括基质灵活性和有价值的生物质副产品.
- 优化LA生产对于可持续地满足工业需求至关重要.
研究的目的:
- 审查Rhizopus物种对乳酸生产的近期进展.
- 探索代谢途径,发酵策略和生物过程优化用于真菌LA合成.
- 分析大规模真菌LA生产的挑战,机遇和技术经济可行性.
主要方法:
- 关于以Rhizopus为基础的乳酸发酵的文献综述.
- 对参与LA合成的代谢和酶途径的分析.
- 检查生物过程参数 (营养素,pH,形态) 和发酵模式.
- 讨论下游加工,扩大规模的挑战和技术经济评估.
主要成果:
- 树类物种从各种可再生基质中显示出高效的LA生产.
- 生物工艺参数的优化显著提高了LA产量和生产率.
- 高细胞密度发酵和下游加工的进步提高了回收和纯度.
- 技术经济分析表明,工业规模的真菌LA生产具有潜在的可行性.
结论:
- 基于树的发酵是一种有前途的可持续途径,可用于工业乳酸生产.
- 对代谢工程和过程优化的进一步研究可以提高效率并降低成本.
- 扩大规模和技术经济可行性研究对于商业化至关重要.
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