三甘油糖相关指数与类风湿性关节炎死亡风险的关联:使用NHANES数据库进行前性队列研究
Feng Sun1, Chen Li2, Shengnan Ren3
1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Rheumatology (Oxford, England)
|December 3, 2025
概括
胰岛素抵抗 (IR) 与类风湿性关节炎 (RA) 患者的死亡率较高有关. 甘油三-葡萄糖 (TyG) 指数有效预测所有原因和心血管疾病死亡,有助于在RA管理中的风险分层.
科学领域:
- 类风湿病学 类风湿病学
- 心血管疾病 心血管疾病
- 代谢综合征是代谢综合征的一种.
背景情况:
- 胰岛素抵抗 (IR) 在类风湿性关节炎 (RA) 中很常见,并与心血管并发症有关.
- 甘油三糖 (TyG) 指数是IR的新兴替代品,但它们在RA中的预后价值尚未确定.
研究的目的:
- 调查TyG相关指数在预测RA患者死亡率中的预后作用.
- 在RA风险分层中建立TyG指数的潜在值.
主要方法:
- 从NHANES数据库 (1999-2018) 中分析了764名RA参与者.
- 利用了卡普兰-梅尔曲线,受限立方线和考克斯比例危险模型.
- 评估了TyG指数 (TyG,TyG-WHtR,TyG-WC,TyG-BMI) 与任何原因/心血管死亡率之间的关联.
主要成果:
- 较高的TyG和TyG-WHtR与显著较低的生存率有关.
- 提升的TyG独立预测了所有原因 (HR=1.60) 和心血管死亡率 (HR=2.36).
- 观察到心血管死亡率与TyG-WHtR,TyG-WC,TyG-BMI之间的非线性关系;因BMI,饮酒,种族和教育而显著影响修改.
结论:
- 与TyG相关的指数显示了RA患者死亡率的显著预后价值.
- 对TyG指数的特定值可以帮助预测死亡风险.
- TyG替代品是RA管理中有效的临床风险分层的潜在生物标志物.
相关概念视频
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
01:26Atherosclerosis III: Management
296
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
296
01:21Rheumatic Heart Disease III: Medical Management
267
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
267
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
521
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
521
01:12Relative Risk
1.8K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
1.8K