纵向基于血液的生物标志物和主观认知衰退的临床进展
Calvin Trieu1,2,3,4, Argonde C van Harten1,2, Mardou S S A van Leeuwenstijn1,2
1Alzheimer Center Amsterdam, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
JAMA network open
|December 3, 2025
概括
像pTau217和GFAP这样的血液生物标志物对跟踪主观认知衰退 (SCD) 个体的阿尔茨海默病 (AD) 进展和认知衰退充满希望. 它们的纵向变化与疾病进展相关,有助于早期干预.
科学领域:
- 神经科学和神经病学 神经科学和神经病学
- 生物标志物发现发现
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 基于血液的生物标志物对于识别阿尔茨海默病 (AD) 和监测其进展至关重要,即使是在临床前阶段.
- 主观认知衰退 (SCD) 代表了认知障碍的早期阶段,通常是轻度认知障碍 (MCI) 或痴呆症之前.
- 了解SCD的纵向生物标志物变化对于早期检测和干预至关重要.
研究的目的:
- 研究SCD患者血生物标志物的纵向变化.
- 评估这些生物标志物轨迹与认知衰退之间的关联.
- 确定生物标志物变化对MCI或痴呆症临床进展的预测价值.
主要方法:
- 对298名患有SCD的人进行前性队列研究 (主观认知障碍队列).
- 每两年一次的血生物标志物收集:Aβ42/40,pTau217,GFAP和NfL.
- 每年进行认知评估和诊断评估,平均随访时间为4.8年.
- 由PET或CSF确定的粉样状况.
主要成果:
- 与SCD和粉样蛋白阳性 (A+) 个体相比,与粉样蛋白阴性 (A-) 个体相比,SCD和粉样蛋白阳性 (A+) 个体的基线水平较高,pTau217,GFAP和NfL的增加更快.
- 在pTau217和GFAP的纵向增加与所有测量领域的认知衰退有关.
- 对于pTau217,GFAP和NfL的更的斜坡显着与进展到MCI或痴呆症的风险增加有关.
结论:
- 纵向血pTau217和GFAP是监测SCD患者阿尔茨海默病病理学的宝贵生物标志物.
- 这些生物标志物的变化与认知衰退和临床进展相关,支持它们在早期干预策略中的使用.
- 这些发现突出了血液生物标志物的潜力,用于早期发现AD和疾病管理.
相关概念视频
01:26Longitudinal Studies
449
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
449
01:26Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
02:20Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K
01:30Cognitive Development During Adulthood
749
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
749
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
763
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
763
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
521
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
521