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暴露前预防 (PrEP) 相关的艾滋病毒监测和自我检测

Yusheng Zhu^1,2, Jarrett Sell³

¹Department of Pathology and Laboratory Medicine, Penn State University College of Medicine, Hershey, PA, United States.

Clinical chemistry

|December 3, 2025

概括

人类免疫缺陷病毒 (HIV) 暴露前预防 (PrEP) 使用抗病毒药物来预防HIV. 新的长效注射剂和改进的艾滋病毒检测,包括自我检测,提高了PrEP的有效性和可访问性,以预防艾滋病毒.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
药理学药理学是指药理学的学科.

背景情况:

人类免疫缺陷病毒 (HIV) 暴露前预防 (PrEP) 涉及抗病毒药物,以防止高危人群感染HIV.
目前的口服PrEP药物面临着坚持性挑战,这促使开发长效注射替代品.
定期进行艾滋病毒检测对于启动,重新启动和维持PrEP治疗至关重要.

研究的目的:

审查当前的实践和艾滋病毒暴露前预防 (PrEP) 的最新进展.
突出不断发展的药物和测试技术在提高PrEP有效性的作用.
讨论改善PrEP可访问性和吸收的策略.

主要方法:

关于HIV PrEP药物和测试策略的当前文献的综述.
分析与口服PrEP相关的坚持挑战.
评估新兴的长效注射PrEP选择和新的艾滋病毒检测方法.

主要成果:

与每日口服治疗方案相比,长效注射PrEP药物有望改善坚持治疗.
使用各种艾滋病毒检测方法,包括实验室检测,快速检测,以及越来越多的艾滋病毒自我检测 (HIVST).
提供者管理的测试可能是PrEP吸收的障碍,这强调了可访问的自我测试选项的重要性.

结论:

艾滋病毒Prep和相关监测是全面的艾滋病毒预防战略的基本组成部分.
需要在PrEP药物方面取得进展,例如新型长效药物和广泛中和抗体,以进一步提高疗效.
提高PrEP服务的可访问性和开发高灵敏度的HIV测试,特别是基于核酸的HIVST,对于优化HIV预防结果至关重要.

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