氧化应激与先进的糖化终端产品积累和大动脉狭窄症的严重程度有关,在同时患有2型糖尿病的患者中

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R Chudy¹, M Zuwala¹, A Undas^2,3

¹Students' Scientific Group of Thromboembolic Disorders, Jagiellonian University Medical College, Cracow, Poland.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

|December 3, 2025

概括

糖尿病 (DM) 在患有严重大动脉狭窄症 (AS) 的患者中显著增加了氧化应激. 这项研究在患有DM的AS患者的血液和大动脉膜中发现了氧化脂 (oxPL) 和其他标记物的较高水平,将其与疾病严重程度联系起来.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
生物化学生物化学

背景情况:

糖尿病 (DM) 是一种已知的大动脉狭窄症 (AS) 的风险因素.
氧化应激与DM中膜退化的进展有关.
需要进一步调查DM,氧化应激和AS严重程度之间的关系.

研究的目的:

评估严重AS患者的DM是否与氧化应激增加有关.
为了在AS患者与没有DM之间比较循环血液和大动脉组织中的氧化应激标志物.
研究氧化应激标志物,血糖控制和AS严重程度之间的相关性.

主要方法:

七十名严重的AS患者 (40名2型DM患者,30名没有) 接受了大动脉置换.
测量了氧化脂 (oxPL),骨髓氧化酶 (MPO),高级糖化终产物 (AGEs) 和可溶性受体 (sRAGE) 的循环水平.
对oxPL和AGE的膜表达被评估,使用对大动脉样本的免疫染色.

主要成果:

与没有DM (AS-nonDM) 的AS患者相比,患有DM (AS-DM) 的AS患者的血清oxPL,MPO,血AGE和sRAGE显著增加.
在AS-DM患者中,oxPL和AGE的膜表达明显更高.
升高的膜氧化物PL与较高的血清氧化物PL和MPO水平相关,以及AS严重程度 (下大动脉膜区域).

结论:

在严重的AS患者中,同时发生的DM与血液循环和大动脉组织中显著增强的氧化应激有关.
在AS-DM患者中增加的膜oxPL表达与全身氧化应激和较差的血糖控制相关.
这些发现突出了氧化应激在DM相关的AS进展和严重性中的关键作用.

关键词:

先进的糖化最终产品.大动脉狭窄症 (大动脉狭窄症)在糖尿病中,糖尿病是血糖性糖尿病.这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.有氧化脂类的酸盐.

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