Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

236
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
236
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

369
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
369
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

297
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
297

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Host and Environmental Drivers of Gut Microbiome Variation in Wild Anolis Lizards.

Molecular ecology·2026
Same author

Early Screening of Sleep-Disordered Breathing Using a Smartphone-Based Portable System in Stroke Patients and Its Relevance for Rehabilitation: A Prospective Observational Study.

Sensors (Basel, Switzerland)·2026
Same author

Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias.

Neurology·2026
Same author

Comparison meta-analysis of two swept-source optical coherence biometers.

Indian journal of ophthalmology·2025
Same author

Virtual Reality-Based Neurorehabilitation Support Tool for People With Cognitive Impairments Resulting From an Acquired Brain Injury: Usability and Feasibility Study.

JMIR neurotechnology·2025
Same author

In-lab Evaluation of New Tattoo Skin Electrodes for Measuring Masticatory Electromyographic Activity.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
查看所有相关文章

相关实验视频

Updated: Jan 9, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K

基于多变量模型的工具,使用多模式生理睡眠数据预测心血管结果.

Daniel Romero, Raimon Jane

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed
    概括
    此摘要是机器生成的。

    阻塞性睡眠呼吸暂停 (OSA) 患者可能有更好的心血管疾病 (CVD) 风险预测通过使用多个睡眠指标超出呼吸暂停-低呼吸指数 (AHI). 来自多睡眠学的新型生物标志物改善了心血管疾病风险分层.

    更多相关视频

    Author Spotlight: IntelliSleepScorer &#8212; A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research
    04:54

    Author Spotlight: IntelliSleepScorer — A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research

    Published on: November 8, 2024

    948
    Assessing the Accuracy of Fitness Smartwatch Data for Cardiovascular and Physical Activity Monitoring: A Validation Study in Digital Health
    05:51

    Assessing the Accuracy of Fitness Smartwatch Data for Cardiovascular and Physical Activity Monitoring: A Validation Study in Digital Health

    Published on: February 21, 2025

    1.2K

    相关实验视频

    Last Updated: Jan 9, 2026

    Multi-Modal Home Sleep Monitoring in Older Adults
    07:40

    Multi-Modal Home Sleep Monitoring in Older Adults

    Published on: January 26, 2019

    8.1K
    Author Spotlight: IntelliSleepScorer &#8212; A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research
    04:54

    Author Spotlight: IntelliSleepScorer — A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research

    Published on: November 8, 2024

    948
    Assessing the Accuracy of Fitness Smartwatch Data for Cardiovascular and Physical Activity Monitoring: A Validation Study in Digital Health
    05:51

    Assessing the Accuracy of Fitness Smartwatch Data for Cardiovascular and Physical Activity Monitoring: A Validation Study in Digital Health

    Published on: February 21, 2025

    1.2K

    科学领域:

    • 睡眠医学 睡眠医学
    • 心脏病学 心脏病学
    • 生物标志物发现发现

    背景情况:

    • 阻塞性睡眠呼吸暂停 (OSA) 与心血管疾病 (CVD) 有关,但呼吸暂停-低呼吸指数 (AHI) 可能不能完全反映长期心血管疾病风险.
    • 目前对OSA患者的风险评估可能会从纳入更详细的生理睡眠数据中受益.

    研究的目的:

    • 确定阻塞性睡眠呼吸暂停 (OSA) 患者心血管疾病 (CVD) 结果的与睡眠相关的新生理预测因子.
    • 开发一个更准确的心血管疾病风险分层模型,超出标准的呼吸暂停-呼吸暂停指数 (AHI).

    主要方法:

    • 利用多式联络数据库,包括多睡眠学 (PSG) 度量,临床数据和风险因素,平均随访10年.
    • 采用两步的特征选择过程:最初删除无关特征,然后使用LASSO进行信息特征选择.
    • 一种基于包装的方法选择了最终的模型,使用重复持久验证,达到75.3%的准确性和78.0%的AUC与10个特征.

    主要成果:

    • 除了传统风险因素 (性别,年龄,BMI,糖尿病) 之外,确定了关键预测因素.
    • 重要的新生物标志物包括夜间平均SPO2 (总和NREM),呼吸暂停期间的心率与SPO2下降,血压和REM/NREM睡眠期间中央呼吸暂停的频率.
    • 该模型在预测心血管疾病结果方面表现强.

    结论:

    • 与单独的AHI相比,整合多式睡眠生理指标可以提高OSA患者的心血管风险分层.
    • 这些发现使OSA患有心血管疾病风险的患者能够进行更精确的临床干预.
    • 发现的新型生物标志物为改进的诊断和预后工具提供了潜力.