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    此摘要是机器生成的。

    早期发现自闭症谱系障碍 (ASD) 是一个挑战. 这项研究发现,在6至11岁的儿童中,特定年龄的形态连接性显示出使用sMRI数据改善ASD诊断的希望.

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    科学领域:

    • 神经科学是一个神经科学.
    • 医疗成像医学成像
    • 发育障碍 发育障碍 发展障碍

    背景情况:

    • 自闭症谱系障碍 (ASD) 是一种常见的神经系统疾病,早期发现具有挑战性.
    • 目前的诊断方法依赖于各种生理和医学成像信号,经常考虑患者的年龄和症状严重程度.

    研究的目的:

    • 调查年龄对自闭症谱系障碍 (ASD) 诊断的影响.
    • 评估形态特征 (MF) 和形态连接特征 (MCF) 在特定年龄的ASD诊断中的有效性.

    主要方法:

    • 利用了来自ABIDE-I和ABIDE-II数据库的结构磁共振成像 (sMRI) 数据.
    • 分析了三个年龄组的数据:6-11,11-18岁和6-18岁.
    • 在预处理的MF (592个对象) 和MCF (10,878个对象) 上使用随机森林 (RF) 分类器.

    主要成果:

    • 6-11岁的年龄组在ASD诊断中表现出优异的表现,与其他年龄组相比,MF和MCF都表现出更好的表现.
    • 形态连接特征 (MCF) 在最年轻的年龄组中显示出特别强大的诊断潜力.
    • 在6-11岁的年龄组中,RF分类器实现了75.8%的准确性,83.1%的F1得分,86%的回忆率和80.4%的精度.

    结论:

    • 年龄特异性分析,特别是侧重于形态连接性,是改善自闭症诊断的有希望的途径.
    • 这些发现表明,不同的发育阶段可能会影响与ASD相关的大脑形态的表现.