人工门取代尿道结口:一种新的方法来防止尿道逆流
概括
新的被动尿道,蝶和帽子,防止急性囊切除术后的反流. 这些人造尿路结 (UVJ) 恢复了单向的尿流,这对于预防脏并发症至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗器械设计 医疗器械设计
背景情况:
- 激进囊切除术往往需要切除尿路结节 (UVJ),从而导致膀回流.
- 目前的膀重建技术不能充分解决囊切除术后的逆流,风险脏并发症.
研究的目的:
- 为人工膀 (AB) 设计,制造和评估被动性尿路 (蝶和帽) .
- 评估这些门在防止反流和确保单向尿流的有效性,如果没有本地UVJs.
主要方法:
- 对于门设计优化的有限元法 (FEM) 模拟.
- 门原型的3D打印.
- 在人造膀模型中的反流,泄漏和流量率的体外表征.
主要成果:
- 蝶和盖都表现出有效的反倒流能力,体积损失小于0.3%.
- 蝶显示出稍微更好的反流预防,并允许膀填充.
- 与生理学数据相比,这两种门设计都将尿液流量到AB降低了46% (蝶) 和57% (头顶).
结论:
- 被动尿管提供了一个有希望的解决方案,在激进囊管切除过程中去除UVJ后恢复尿功能.
- 这些新型门可以有效地预防膀外流,减轻脏损伤的风险.
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