通过因果平方一致性评估大脑血管方向合,在手术上更换大动脉门后出现静音中风的患者中评估因果平方一致性
概括
经过心脏门手术的患者可能有大脑自身调节 (CA) 功能受损,影响到大脑的血流控制. 这种损伤与手术性大动脉置换 (SAVR) 之后的中风风险有关.
科学领域:
- 神经科学是一个神经科学.
- 心血管外科心血管外科
- 医疗成像医学成像
背景情况:
- 手术性大动脉置换 (SAVR) 患者面临中风风险,通常通过扩散权重磁共振成像 (DW-MRI) 检测到.
- 建议在SAVR后维持大脑自身调节 (CA),但其与最近的缺血病变的联系尚不清楚.
研究的目的:
- 通过近期SAVR患者的因果交叉谱分析,研究闭环脑血管控制.
- 评估CA标志物与DW-MRI检测到的最近缺血性脑病变之间的关联.
主要方法:
- 分析了23名SAVR患者 (19名男性,年龄57±16岁),使用因果交叉谱分析平均动脉压 (MAP) 和平均脑血速 (MCBv).
- 测量是在休息状态下 (REST) 和在活动站立测试 (STAND) 中进行的.
- 计算的传统连贯性 (K2),从MAP到MCBv的因果连贯性,以及与CA相关的频段中的MCBv到MAP.
主要成果:
- 最近患有缺血病变的患者 (中风组) 在STAND期间与REST相比,MCBv变异性增加.
- 在STAND期间,中风患者表现出无法将MAP和MCBv变异性脱,这表明CA损伤.
- 在高频带 (0.15-0.4 Hz) 中观察到合强度的趋势,不论相互作用方向如何.
结论:
- 在SAVR患者中,最近缺血性脑损伤的脑自调可能会降低.
- 因果交叉光谱分析有效地研究了SAVR后的闭环MAP-MCBv关系和微循环损伤.
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