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模拟的流动诱导变形的同质附着细胞

Ema Huscavova, Tomas Vicar, Jaromir Gumulec

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|December 3, 2025

概括

我们开发了一种流体结构相互作用 (FSI) 模型,以模拟在流动下细胞变形. 一向合为分析细胞力学提供了对双向合的计算效率高的替代方案.

科学领域:

细胞力学和生物物理学
计算机建模和模拟.
微流体和基于细胞的测定.

背景情况:

细胞机械特性对于理解细胞功能和疾病至关重要.
在流动下模拟细胞行为需要精确的流体结构相互作用 (FSI) 建模.
定量阶段成像 (QPI) 在模拟中提供了切实可行的细胞形态的基本数据.

研究的目的:

开发和验证流体结构相互作用 (FSI) 模型,用于模拟剪切流中的同质粘附细胞变形.
在FSI模拟细胞力学中比较单向和双向合方案.
评估不同合方法的精度和计算成本之间的权衡.

主要方法:

开发了一个FSI模型,使用OpenFOAM (有限体积) 进行流体动力学和FEniCS (有限元素) 进行结构分析.
使用preCICE库合流体和固体域.
整合了从定量阶段成像 (QPI) 获得的实验数据,以实现现实的细胞形态.
对比单向 (无反数据传输) 和双向 (双向数据交换) 合方案.

主要成果:

一向合可以接近双向合的结果,弹性模量略有增加.
一向合显著降低了计算复杂性和模型简化.
开发的FSI模型可以实现切割流下细胞变形的现实模拟.

结论:

一向合是一种最佳且计算效率高的方法,用于对细胞力学数据的高吞吐量分析.
可靠的FSI模拟对于推进基于细胞的测试至关重要.
这项工作为更复杂的模型奠定了基础,包括粘性弹性和活性细胞组件.

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