Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Statistical Methods to Analyze Parametric Data: ANOVA01:12

Statistical Methods to Analyze Parametric Data: ANOVA

Analysis of Variance, or ANOVA, is a powerful statistical technique used to analyze parametric data, primarily in research and experimental studies. It's designed to compare the means of two or more groups, assisting researchers in identifying any significant differences between these group means. There are two main types of ANOVA based on the complexity of the analysis: one-way and two-way.
One-way ANOVA is applied when a single independent variable or factor is scrutinized. It compares the...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Mathematical Modeling: Problem Solving01:29

Mathematical Modeling: Problem Solving

Mathematical modeling transforms real-world scenarios into mathematical expressions, allowing for structured problem-solving and analysis. This process involves defining the situation, assigning variables to measurable quantities, selecting an appropriate model, and solving the resulting equation. Such models are invaluable in finance, providing precise methods to evaluate investments, loans, and repayment structures.A widely used example is the calculation of fixed monthly payments on a loan,...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Prognostic Model Development for Continuous Carotid Intima-Media Thickness: A Graph-Driven Self-Supervised Learning Approach.

IEEE journal of biomedical and health informatics·2025
Same author

In silico Deployment Modeling of an Everolimus Coated Balloon.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Statistical and Machine Learning Approaches for Virtual Population Generation in In-Silico Cardiovascular Trials.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Immunometabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease Comorbidity.

Biological psychiatry global open science·2025
Same author

A Multiscale Parametric Study to Drug Delivery Modeling in Stented Arteries.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Precision Gait Analysis and Event Detection Using IMUs: A Comparative Evaluation with Insole Pressure Readings.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
查看所有相关文章

相关实验视频

Updated: Jun 29, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.6K

对参数组织建模的计算框架.

Vasileios S Loukas, Grigorios G Kotoulas, Lambros Athanasiou

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed
    概括
    此摘要是机器生成的。

    这项研究引入了用于心血管疾病研究的自动化3D血管建模框架. 它提高了个性化医学和人口规模研究的可复制性和可扩展性.

    更多相关视频

    Voxel Printing Anatomy: Design and Fabrication of Realistic, Presurgical Planning Models through Bitmap Printing
    11:36

    Voxel Printing Anatomy: Design and Fabrication of Realistic, Presurgical Planning Models through Bitmap Printing

    Published on: February 9, 2022

    3.2K
    Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
    10:23

    Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

    Published on: December 1, 2023

    928

    相关实验视频

    Last Updated: Jun 29, 2026

    Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
    10:51

    Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

    Published on: April 23, 2021

    4.6K
    Voxel Printing Anatomy: Design and Fabrication of Realistic, Presurgical Planning Models through Bitmap Printing
    11:36

    Voxel Printing Anatomy: Design and Fabrication of Realistic, Presurgical Planning Models through Bitmap Printing

    Published on: February 9, 2022

    3.2K
    Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
    10:23

    Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

    Published on: December 1, 2023

    928

    科学领域:

    • 心血管研究的心血管研究.
    • 计算生物学是一种计算生物学.
    • 医学成像分析分析 医学成像分析

    背景情况:

    • 心血管疾病,特别是冠心病 (CHD),是全球主要的死亡原因.
    • 数字双胞胎技术和先进的计算框架为血管建模和个性化治疗提供了新的途径.
    • 现有的血管建模方法在可复制性,可扩展性和计算效率方面存在局限性.

    研究的目的:

    • 为自动化3D血管建模和定量分析提供高性能计算框架.
    • 解决当前血管建模技术在可复制性,可扩展性和效率方面的局限性.
    • 为了促进高通量分析和支持心血管研究中的精准医学.

    主要方法:

    • 参数计算机辅助诊断 (CAD) 建模与自动化数据处理的整合,用于从成像数据生成3D模型.
    • 自动化表面重建,度量提取和几何优化,以最大限度地减少人工干预.
    • 开发一个支持标准化数据格式的模块化框架,以便无地集成到计算工作流中.

    主要成果:

    • 该框架能够在规模上快速和可复制的3D血管模型生成.
    • 自动化过程显著减少了人工干预,允许进行高吞吐量分析.
    • 验证证实了重建几何形状的准确性和一致性,测量偏差最小.

    结论:

    • 拟议的框架增强了可扩展性,并减少了对血管建模的计算需求.
    • 它支持人口规模研究,预测建模和in silico临床试验.
    • 该工具通过为血管分析提供强大的解决方案,推进精准医学和计算心血管研究.