Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neuron Structure01:30

Neuron Structure

17.6K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
17.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

An electrophysiological and proteomics roadmap for human induced glutamatergic neurons: fine-tuning of culture conditions for pathophysiological studies.

Cell death discovery·2026
Same author

Hierarchical Afferent Connectivity Drives Population-Wide Bursting Dynamics in a Computational Model of Human-Derived Excitatory Neuronal Networks.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Advancing neuroengineering with Neuromorphic Twins.

Nature communications·2026
Same author

HiPSC-Derived Neuronal Networks on Micro-Electrode Arrays: a Functional Model of the Ischemic Penumbra.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Functional Connectivity of Electrically Stimulated HiPSCs-Derived Neuronal Networks.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Protocol for the enhanced analysis of electrophysiological data from high-density multi-electrode arrays with nicespike and spikeNburst.

STAR protocols·2025

相关实验视频

Updated: Jan 9, 2026

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells
08:48

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells

Published on: August 16, 2018

12.7K

人类衍生的神经球体中的功能连接性

Giulia Parodi, Giorgia Zanini, Linda Collo

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed
    概括

    这项研究引入了使用人类干细胞的3D脑芯片模型. 该模型揭示了神经元抑制如何影响大脑网络连接和拓,为大脑功能提供了洞察力.

    科学领域:

    • 神经科学是一个神经科学.
    • 干细胞生物学 干细胞生物学
    • 生物工程是生物工程.

    背景情况:

    • 大脑功能依赖于复杂的神经网络相互作用.
    • 了解神经连接对于神经科学进步至关重要.
    • 现有的模型往往缺乏人类大脑的维度和异质性.

    研究的目的:

    • 开发一个包含异质性的3D脑芯片模型.
    • 研究同质和异质神经网络的功能连接.
    • 探索神经元抑制对网络拓学的影响.

    主要方法:

    • 利用人类诱导的多能干细胞 (hiPSCs) 来衍生神经网络.
    • 构建的3D神经球体,均 (仅刺激神经元) 和异质 (刺激和抑制神经元).
    • 计算功能连接属性和网络拓.

    主要成果:

    • 同质和异质的神经球体都表现出小世界网络特性.
    • 神经元抑制显著增加了文化中的连接数量.
    • 异质性和维度性被成功地纳入了芯片上的大脑模型.

    结论:

    更多相关视频

    Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
    10:08

    Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

    Published on: February 24, 2021

    6.7K
    Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
    05:40

    Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

    Published on: May 5, 2022

    4.4K

    相关实验视频

    Last Updated: Jan 9, 2026

    Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells
    08:48

    Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells

    Published on: August 16, 2018

    12.7K
    Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
    10:08

    Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

    Published on: February 24, 2021

    6.7K
    Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
    05:40

    Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

    Published on: May 5, 2022

    4.4K
    • 开发的芯片上的大脑模型有效地模仿了活体大脑的关键特征.
    • 神经元抑制在塑造神经网络拓学方面发挥着至关重要的作用.
    • 该模型为研究与连接相关的神经障碍提供了基础.