使用手术内NIR-II光视频成像和快速计算的引导性食道切除术
Feifei Wang1,2, Ian Yu Hong Wong3, Haoran Liu1
1Materials Innovation Institute for Life Sciences and Energy, The University of Hong Kong, Shenzhen 518048, China.
概括
近红外II (NIR-II) 光成像通过可视化胃管中的血液流动来增强食道切除术. 这种技术指导外科医生切除不良 perfused 组织,减少静脉漏和改善患者的结果.
科学领域:
- 手术瘤学手术瘤学
- 医疗成像医学成像
- 胃肠病学 胃肠病学
背景情况:
- 与传统的NIR-I成像相比,短波红外/近红外II (SWIR/NIR-II) 光成像提供了更高的对比度和深度.
- 在NIR-II中减少光散射和组织自光增强可视化能力.
- 临床翻译NIR-II成像对于推进外科手术指导至关重要.
研究的目的:
- 临床翻译NIR-II光成像用于指导食道切除术.
- 使用手术内NIR-II视频成像来评估食道癌患者胃管道 (GC) 中的血液 perfusion.
- 评估NIR-II成像对手术决策和患者结果的影响.
主要方法:
- 在接受食道切除手术的患者内静脉注射绿色氨酸 (ICG).
- 在手术期间使用NIR-II光技术进行视频成像.
- 使用主要成分分析 (PCA) 快速分析GC中的血液流动模式.
主要成果:
- 在1分钟内,NIR-II视频成像清晰可视化了GC的空间和时间血流.
- 在手术期间的PCA揭示了GC中明显的 perfusion 模式.
- 针对性切除不良 perfused 组织和知情的重建减少了道泄漏的风险.
结论:
- NIR-II光成像为食道切除术提供了独立于操作者的实时指导.
- 这种技术通过客观评估组织输液来提高外科精度.
- 通过NIR-II成像改进的外科指导有潜力显著减少危及生命的并发症,如静脉漏.
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